ProRes 422 versus ProRes 422 HQ ?
1: Export to Apple Pro Res 422 for final output (desktop and later to the web) or something else) the best option to keep a good final copy of my masterpiece.
2. Export to ApplePro Res 422 HQ (only if it is intended for further manipulation) otherwise an overkill.
Mac Pro, Mac OS X (10.6.7), FCS 7