Alan,
So you're not after the Chicago Blues harmonica sound...
The fat sound you mentioned would definitely come from a vacuum tube (especially a push-pull configuration) guitar amp and speaker cone breakup (especially with an alnico magnet guitar speaker). However, the terms fat and clean are contradictory, exact opposites. Fat refers to harmonic distortion as in the Chicago Blues harp sound achieved with a crystal mic, vacuum tubes, and alnico magnet guitar speaker cone breakup. Clean is the exact opposite of distorted, fat, fuzzy, or overdriven sound. To achieve a clean harmonica sound, Fender vacuum tube guitar amps are famous for their clean sound. A condenser mic would give the best clean sound with the most detail, but may be hard to run through a guitar amp because condensers require phantom power. You could run a condenser mic into a PreSonus TUBEPre and the output of the TUBEPre into a guitar amp's input. The TUBEPre's drive control could be adjusted to give you any amount of fat up to and including overdrive. Any vacuum tube guitar amp and giutar speaker, though, is going to add some harmonic distortion. A transistor guitar amp would tend to be cleaner sounding. Or you could skip the guitar amp all together, and go from the TUBEPre to the line level audio in port on your Mac.
See
http://www.appliedmic.com
for AMT's HR1, HR2, & HR16 condenser mics for harmonica and use their "Mic/Instrument SEARCH" feature to find harmonica microphones on their website.
I couldn't find any references to a Sennheiser "451" microphone except for the recording of bass amp speaker cabs. Sounds to me like the "451" might be a bass/kick drum mic. Perhaps it is a discontinued microphone no longer made by Sennheiser. The only Sennheiser 451 I could find was the HDC451, a pair of noise cancelling headphones. Did you mean the Sennheiser MK421 II mic? It is an industry standard studio recording microphone. Though it is rather large and not handheld making it rather difficult to hold along with a harmonica.
I saw John Mayall on PBS last night playing his harmonica through a handheld Shure SM58 vocal mic.