Add me to the list. My wife and I are both running SL 10.6.7, Safari 5.0.5, Glims 1.0b28 added, Extensions on. My wife has no Extensions added, and plug-ins we both have installed are QuickTime, Java, Java 2, iPhotoPhotocast, Google Earth, Microsoft Office Live, Quarts Composer, and Shockwave Flash and Shockwave Director. Extensions I have are AdBlock, Translate, Papers, InvisibleHand, TinEye, JavaScript Blacklist, Fireballed, and Click To Flash. Auto-update is on, and all the extensions are the latest version. I also have Citrix and Silverlight plugins installed.
Her MacBook (2006 ed) has 2GB of RAM, Safari opens with 60MB or so and after a few days of intermittent use (with all windows/tabs closed) is using 230MB of real RAM.
My MacBook Pro (mid-2009 ed) has 4GB of RAM, Safari opens with 150MB or so and after 5 hours of heavy use (maybe 200 pages loaded, lots of multiple tabs, some YouTube H.264 videos, etc.) and then everything closed is using 700MB of real RAM. If I leave it open with all windows closed for a few days it will be using 1.5-2GB of real RAM.
I’ll be doing more thorough troubleshooting over the next few days, but this is definitely a big issue as I have to quit Safari after every use or my MacBook Pro slows down. This wasn’t always the case, so it’s probably an interaction between an extension or plug-in with Safari 5.0.5.