Yes there was one Firefox victim that I know of.
The difference with Firefox say a user clicks the fake JavaScript window to close it and initiates a download, Firefox will ask before starting the download what to do with it and a option to cancel. This immediately alerts the user something fishy is going on.
Most people realizing it's a Trojan site download will just cancel the download and move on, why we don't here much from Firefox users.
Safari on the other hand just downloads the file, then OS X checks with the user AFTER the fact and perhaps a day or two later when the user thinks to themselves "What's this in my downloads folder...?" OS X says "You downloaded this file such and such day and time.."
I don't know about anyone else, but my memory isn't that good that I bother to remember exact days and times when I clicked a particular download link or not.
Problem with driveby downloads, fast connections, Safari's automatic and small downloads window is one likely won't see the download occur, especially if they click on the bigger window, making the downloads window go to the rear.
What if the malware download snuggles in with real downloads?, or god forbid, uses it's same name as a legitimate download on the installer?
Here is a example:
https://secure.wikimedia.com/tricklink
Now look in your downloads folder for file named: osx-pl2303.kext.zip
Firefox users won't get tricked by the link above because a window appear and not allow the download unless the user agree's.
Another thing, the download doesn't have a good description identifying what it is before you run it, it just says "osx-pl2303.kext.zip" some people will know it's a kext file, so people's tendency is to click to see what it is.
It's a Prolific PL-2303 driver for 64 bit Mac OS X by the way from Apple, a small file to demonstrate.
So is the rash of Trojan downloads a issue related to Safari?
Lets say the way Safari is makes it easier to get Trojans on a Mac than other browsers that warn of a download before commencing.
Since most Mac users use the browser that comes bundled with a new machine, or out of severe loyalty to Apple, will get hit more often by these Trojans.