Some suggestions to try
- Another USB cable
- Turning off the Epson power for a minute and then back on again
- Removing the print queue and adding it again
- Resetting the printing system
Note that when you reset the printing system the printers in Print & Fax are deleted, but not their printer drivers. So you don't need to run the printer driver installers again, you just need to add the print queues again. For a USB connected printer, this can be done by simply unplugging the USB cable and plugging it back into the Mac agian.
How to Reset the Printing System
1. Open System Preferences > Print & Fax
2. Move your mouse over the Printers list
3. Hold down the Control button and click the mouse
4. Click the "Reset printing system ..." popup
5. Restart your Mac