Hi all,
I realise this topic is dated but hopefully it'll help someone out there with a 5750 still kicking around.
Found this thread after helpful advice from Andrew Humphreys as I've had artifacting issues with my Mid-2010 27" iMac for quite a while.
The first time the problem occured, the 5750 was replaced under Apple Care. I also had a hard-drive nearly die but luckily caught it in time because Apple run their devices way too hot. After the replacement GPU (and hard-drive), I installed iStat and cranked up the minimum fan speed to keep things cool.
Fast forward a few more years and artifacting is getting worse but, like most of you, mainly during the cooler months which made me think it was drivers and not heat. Unfortunately there was no real way to easily stress the system to prevent lockups (they'd happen frequently and sometimes with minimal artifacting) so I researched on modding the GPU to prevent it downclocking or undervolting.
I had recently swapped out my 2TB WD Black for a 1TB Samsung 850 EVO SSD (after moving to a NAS for media and backups) and was determined to get a few more years out of the Mac so cleaned up the heatsinks and reapplied thermal paste to both the GPU and CPU.
But Winter came and nope, still no good so found the details for flashing the BIOS to either run a higher stock clock speed or overvolt. After loading the stock BIOS, I figured out it must've just been due to the drivers using the wrong profile so set all 4 profiles to 700Mhz on core, 1000Mhz on RAM and 1v on die.
Unfortunately it took a bit of time to do all this as I had to load W10 onto a new partition but rebooted and no more artifacts.
Let's see how long this lasts!