Sorry, but I just cannot believe Chrome can have any influence in this at all. Chrome isn't part of the OS, and, therefore, needs the OS to get to the hard drive. So, it will call upon the OS in exactly the same way as any other piece of software (neglect to do this would, of course, result in an error). I think this issue lies with WD drives for 100% (that is to say, in Californiak's case). Ok, it might be peculiar for Chrome's behaviour to be different to that of other software, but still, I don't think the essence of the matter is with Chrome. As for WD drives (and especially drives within the Passport series) I have had enough personal experience to last me a lifetime.
As long-time followers of this thread may know, I do NOT run Lion, yet have the very same issues as those listed here. I have had three totally different FireWire drives. All drives were capable of using FireWire 800. Or, at least, that's what looks told me. In case of my iOmega drives, I have had no problem whatsoever. One of them is still working, the other is now disused because of a faulty power supply. That is, in its own, a very sad matter, but apart from that, it has never caused any real issue. Therefore, I've always used these on FW800.
My G-Drive is also working perfectly, apart from some communication halts now and then. It will dismount, but, strangely enough, my iOmega eGo drive, which is bridged to the G-drive, is still available. To get the G-drive back on the desktop, I'll have to unmount the iOmega (logically, not physically) then turn off the G-drive, and then turn that back on. After that, both drives will be back on the desktop.
My WD drive is now in disuse, as it caused nothing but trouble from day one. I have regretted buying it ever since, but as I've bought it in Portugal whereas I live in the Netherlands, going for a refund wasn't a feasible option. The WD drive would mount fine, and data on it could be read, but no more than 500MB could be written to it at any time, no matter whether the individual files themselves were large or small. It seems there was some kind of limit or cap in place for anything over exactly 500MB. On bad days, the cap would be even lower.
Upon seizure, the drive would halt ALL communication, but stay mounted on the desktop. Judging from the LEDs on the front of the drive, one could see it was asleep (like it suffered amnesia -- it just dropped to sleep whilst on shift). However, the drive didn't spin down any of those times. The only remedy was to forcibly detach the drive (i.e. yanking the cable from it). Of course, this would inevitably cause Mac OS X's familiar message to appear, stating the drive had been improperly removed. I quickly came to disregard this message for this drive, however, as at least by doing this, I gained back control over my system.
Once or twice, this drive caused the entire FireWire subsystem to cease functioning until after I'd committed an SMC reset.
For the WD drive, similar issues occurred on FW800 as well as on FW400. On USB, the drive is, at least, somewhat more reliable. Just as long as I prevent it from going to sleep. Because as soon as that happens, the front LEDs freak out and start blinking like crazy (seriously, I didn't think any LED could blink so fast until I saw this for the first time) and the drive says farewell for the day (i.e. it dismounts). So you can imagine I only choose to use that drive if it really is as urgent as can be.
For those of you who might now think that it should be just this particular drive, please stand corrected by me saying that I have had similar issues with no less than 4 identical drives. Fortunately, only the first one is actually mine. I seriously would NEVER buy such a drive again. And PLEASE let this be my urgent advice to any of you out there considering the purchase of a new drive. Avoid WD (Passport) like the plague!