Here is a very slow page in Safari 5.1
Safari before 5.1 has had no problem loading this page:
But in 5.1 requesting this page makes WebProcess start consuming 100%+ of CPU and it takes 105 seconds under Snow Leopard on a 2 x 2.8 GHz Quad-Core Xeon Mac Pro and 65 seconds under Lion on a 2.3 GHz Intel Core i7 MacBook Pro, before the page is ready to do anything (scroll or press a button) with.
To check whether there might be a font or character causing this problem, I have replicated the situation with various subsets of the table being displayed. Displaying 1000 rows speeds the loading, but it still takes about 15 seconds on the Snow Leopard machine, regardless of which 1000 rows are displayed. (These times are over a LAN, so no Internet latency.) Similar problem on a 2.4 GHz Intel Core 2 Duo MacBook.
The loading time is not appreciably decreased if the page is loaded again in succession.
Mac Pro, Mac OS X (10.5.7), iPhone 8GB, Airport Extreme