Hey.. I've spend ours to delite skype, and Skype is making me trouble. How do I once and for all delite skype from safari ???

Skype is a distinct application from Safari. If you don't want Skype simply trash it.

Right click the icon and hit send to trash and then empty the trash.

Skype has nothing to do with Safari. Drag your Skype application to the trash and empty the trash. If Safari is causing problems, select 'reset Safari' under the File menu afterwards.