I have a 3GS & 4S. I set up the 4S as a NEW phone, using the 3GS as a guide for installing m apps and getting them all in the right folders. I try to be consistent so that I can almost locate any app in any folder without looking at the screen.
As a family (extended to include my own kids, my siblings, nephews & nieces) we have a lot of iPhones and I support all of them. With every OS update, i have always set up each phone as NEW, never restored from a backup, simply because features are added/removed with each update, however minor.
Setting up an iPhone as NEW makes no diference in my opinion after updating 50+ handsets -- backgroung processing does and I for one am glad Apple has intro'd iMessage as WhatsApp seem to be a big drain on the battery -- there may be others and I am trying to work through nearly 100 apps (uninstall for a couple of hours, then re-install) on my 4S but it is tedious and depends on my health.
I still believe that being able to force the iPhone into 2G mode will make a big difference as I have only seen the "E" once when turning the WiFi ON/OFF. Yesterday, I turned the WiFi ON and didn't get any signal bars until I turned ON/OFF the Mobile Data option -- I was less than 3-feet away from my Apple Extreme! -- I'm thinking maybe Apple should have stuck to separate handsets for UMTS and CDMA.