Well there's something wrong somewhere.
Last night I downloaded the iPhone 4s .ipsw file manually. Booted my 4s into DFU mode and performed a factory reset of the iPhone through iTunes (holding alt on the keyboard whilst clicking Restore, then selecting the .ipsw file in my downloads folder). When it booted into iOS after the restore, I unplugged it from my mac (so it couldn't receive any data from iTunes) and ran through the setup procedure on the phone . I disabled Siri, location services and set it up as a new iPhone. After this I turned off Bluetooth, Wifi, Notifications, Ping, Facetime and iMessage. I didn't set up any e-mail accounts. Didn't log into the Appstore. Mobile data was switched on though and the SIM card was in. Basically it was just a phone and that was it.
The battery was at 89% and had been calibrated 4 times during the week leading up to this point. During various attempts to fix this problem.
By this time it was 12am so I went to bed and left it on it's own, not plugged in and not charging.
I woke up at 7am to find that the battery was down to 73%! This means the iPhone burnt through 16% in 7 hours! or 1% every 25.2 minutes. If you work that out over the phones 100% battery life, that's only 42 hours on standby (if my calculations are correct) and I hadn't even picked it up once. Nowhere near the 200 hours standby time advertised. I live in an area with good 3G connectivity and couldn't turn off 3G on the phone anyway as Apple have removed that option.
It also gave me a diagnostics error list as long as my arm under Settings-General-About-Diagnostics & Usage-Dianostics & Usage Data.
I've now removed the SIM card and switched on WIFI (as the phone is meant to be sending diagnostic data to Apple). It is now using 1% of battery every 68 minutes. With 100% of charge, this will only give me 73.3 Hours of standby time. Which is a joke!
Luckily I still have my iPhone 4, which is fully functional and working perfectly.
I believe the problem goes deeper than the settigns that users are applying to their devices. This is OS problem that Apple needs to address ASAP.