Received two 4S's (my wife and I) on Friday and set them up with the"whole shabang" of new iOS options and saw the same battery drainproblem as everyone over the weekend and yesterday (with only moderate usage).
Did the common steps that everyone has discussed yesterday (diagnostics-OFF, time zones-OFF, disabled most locations services that I didn't need, did a network settings restore, etc) and finally decided last night to do a battery conditioning - full discharge/re-charge. Started today with the basic settings that I want- bluetooth -ON and the new find my friends-ON. I also have iCloud sync running but no push for e-mails (that's always been a big drain).
By noon today, after a few of phone calls, some music on my way to work and a couple texts, I'm still at 100% and I've been off the charger forabout 4.5 hours. I realize alot of just standby time but even with standby over the last few days it was draining fast. I'm hopeful that the battery has "settled down". We'll see.