Universal Access in System Preferences has setting for doing some very strange things to a screen, and they all have key commands, so if you happen to hit the right set of keys accidentally your monitor can go way weird for no reason that you are aware of.
I hit the keys accidentally that reversed the monitor, making a negative of the usual view. I freaked out until I figured out what was wrong.
So, go to System Preferences, then click on Universal Access. Go down to display amd make sure Black on White is on and that the enhanced contrast slider is set at normal.