Ebook management program Calibre is not communicating with itunes

I have been using Calibre, an ebook management program, with no problem. Now for some reason, when I try to connect to itunes I get an error message...

ERROR: Error: Error communicating with device

Can't get terminology for application (aem.Application(u'/Data File/Alex Backup/Applications (Mac OS 9)/iTunes/iTunes')): Command failed: Application isn't running. (-600)

Traceback (most recent call last):

File "site-packages/calibre/gui2/device.py", line 81, in run

File "site-packages/calibre/gui2/device.py", line 332, in _books

File "site-packages/calibre/devices/apple/driver.py", line 3088, in books

File "site-packages/calibre/devices/apple/driver.py", line 2151, in _get_library_books

File "site-packages/appscript/reference.py", line 578, in __getattr__

File "site-packages/appscript/reference.py", line 260, in referencebyname

File "site-packages/appscript/reference.py", line 229, in connect

File "site-packages/appscript/terminology.py", line 171, in tablesforapp

File "site-packages/appscript/terminology.py", line 143, in aetesforapp

RuntimeError: Can't get terminology for application (aem.Application(u'/Data File/Alex Backup/Applications (Mac OS 9)/iTunes/iTunes')): Command failed: Application isn't running. (-600)

I am running Lion and can get into itunes fine otherwise. I did do a backup of my son's data file and it's in my data file.