Hmm, it's slightly worrying. I'm not sure if it's bad. The reason I emphasised that you don't empty the trash is that I'm stabbing in the dark a bit here! What I would do at this stage is look through ~/Library and find anything you might think is a Preview support file/config file and move it to the trash, then restart Preview - but don't empty the trash coz you may need to restore it afterwards. Some of these things Preview will recreate when it starts again, that's desirable coz whatever is causing the problem we want it to recreated from new. Likely candidates to look through in ~/Library would be Application Support, Caches, Preferences, etc... But have a good trawl through and see what you kind find. Like I said, it's stabbing in the dark a bit, but what else have we got at this point?!