Intermittent problems are often a result of interference. Interference can be caused by other networks in the neighbourhood or from household electrical items.
You can download and install iStumbler (NetStumbler for windows users) to help you see which channels are used by neighbouring networks so that you can avoid them, but iStumbler will not see household items.
Refer to your router manual for instructions on changing your wifi channel or adjusting your multicast rate.
There are other types of problems that can affect networks, but this is by far the most common, hence worth mentioning first.
Thanks for the quick response. I would think channel interference would cause the same symptom when using AirPlay to stream music my Apple TV via my iPad and iPhone as well, but these devices work fine. It's only using AirPlay on my MacBook Pro that creates this issue. I've tried multiple channels and there is no change. Any other thoughts?