"Smart Playlists" are playlists that are automatically updated based on criteria you set and the number of songs/audiobooks/etc. that can go in these playlists can be from 0 to your entire library. "Playlists" are playlists that have to be manually populated by dragging items into it from the main library or another playlist. Both types of playlists have their advantages and disadvantages so how you plan on using the playlist will determine which type to use.
To create a smart playlist that does not contain 'Books & Spoken' you need to go to File -> New Smart Playlist. A window will appear where you set the criteria. In first list box select 'Genre', in the second list box select 'Is Not', and in the third type 'Books & Spoken'.
If you want to use criteria such as 'Kind', 'Last Played' but you do not know their values then go to Edit -> View Options... and select the criteria you want to use. With the exception of 'Name' (of the song) you can rearrange the order columns are shown. Apple has tutorials on their web site and if you select on the following link it will take you to one that shows you how to create smart playlists.
http://www.apple.com/ilife/tutorials/itunes/it2-2.html
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