Cannot save files because of disk error
This week my mac pro started to become flaky. Apps that I use all the time, started having problems saving, then they started having problems opening files. I could drag and drop files on an app and they would open. Cmd+S would sometimes save, sometimes not. If I closed the window without saving, I'd get the warning prompt, select OK to save and the file would save. Printing started flaking. Page setup comes up with a blank dialog, with Printer settings pulldown blank. Trying to print, either nothing would happen or the app would crash. I have run disk verfy - everything checks out. I have repaired permissions, I have run techtool pro. Nothing works. I have done a Cmd-Opt click to start apps for a fresh prefs file. It seems to have started with one app and is showing up in others, mostly Adobe/Microsoft apps, but now Open Office, too. I've had and diagnosed many macs over the years, but this one's got me perplexed. I've got Sophos Antivirus and nothing has been detected....
TIA for any help!
Mac Pro, Mac OS X (10.6.8), 2 x 2.4 GHz Quad-Core / 8GB RAM