I have this identical problem, with the identical scenario as depicted in the OP's screenshot post. I have just migrated (using Migration Assistant) the stock internal HD of a 2007-era Macbook pro running 10.7.4, to a new SSD drive. Running on it just fine, until I attempted to update Firefox. The update wouldn't perform, and that's when I discovered the permissions issue on the .app itself. I see it also on the entire Applications directory as well as System, Users, and Library.
I deleted Firefox.app manually and reinstalled, and the new copy has the correct permissions, and in general everything is working. A repair of the Home folder ACLs and permissions (2 actually) has done nothing, and general permissions repairs also claim to find a few minor incorrect permissions and claim to fix them, but actually don't fix anything and will find them again immediately.
I'm not sure if this is actually something to be concerned about or not... does anyone know? It's certainly not normal that's for sure.