I, too, was perpetually finding these random flashing pixels... after my mid-2010 iMac 27" i5 began restarting itself, nightly.
Had the hard drive sleep set to "never", but the screen set to 15 minutes of inactivity.
Changed screen to "never", and the restarting seems to have ceased... as have the flashing pixels.
All began with upgrade to Mavericks.
Prior to changing the sleep settings, I was continually running utilities which either report "clean" or correct a smattering of minor permissions... following any crashes, system-self-restarts, freezes-and-manual-power-off-restarts.
Now, all seems to have stabilized: Will follow up with reports over time, to see if problem has resolved...