If it's because you were using Office 2004, the eight year old version of Office that was written when Intel processors were not used in Macs, then there will be no fix. Lion dropped support for PowerPC applications, as has been widely reported since Lion's release last August.
You can upgrade Office 2004 to Office 2008 or Office 2011. You can use iWorks 2009 that can open Microsoft files. You can use a number of free applications that are also capable of working with Microsoft documents. You can go back to Snow Leopard, if you have a backup. Or, if you have an external drive or room to add a partition to your current drive, you can install Snow Leopard on it.
Search these forums for more information. If this is your issue, it's been posted and answered several times a day since August 2011.