If I hadn't done this regularly (once a year) I think it would be appropriate to vacuum the machine from ALL enrty ports first.I've put compressed air (from my compressor) into all the openings of my several iMacs without consequence. My compressor has a regulator on it and I keep the PSI at about 60. I start with the slot at the top rear of the machine, move to the A/C hole, then the several ports (USB, Headphone, Firewire, etc.) I also blow into the Superdrive slot. Then I Vacuum the memory slot area thoroughly with the memory modules removed. Earlier this spring I actually took the iMac apart and noticed that the fans get a dust buildup inside the impellors themselves. I don't think you could dislodge the buildup without air directed at them in close proximity