I ran Itunes in safe mode and it worked, but my question is do i always have to open it this way or eventually it will run properly?

If iTunes works in Safe Mode only, there is probably a out-dated plug-in problem.

Try following along with this Apple article -> iTunes: Troubleshooting issues with third-party iTunes plug-ins

I'm having the same problem, but when i follow the troubleshooting guide i'm not finding any plug-ins in the specified folders