How can I disable mouse shortcuts (mission control, etc) in games?

I just installed the new Deus Ex: Human Revolution from the App Store and I'd like to use the miltiple mouse buttons my Logitech mouse has in my game. I can set up the controls to use various buttons in the game, but I also have the same mouse buttons set up in the System Preferences to be used for mouse shortcuts. The problem is, when I try to use the game, the "All Applications" or the "Show Desktop" shortcuts kick in instead of the games setup controls.

How can I disable the Mouse Shortcuts for the system while I'm in the game?