OK just zapped the PRam, no Cigar.
Personally, I did not think it would help. (As previously noted, I tend to agree with those who consider this more of a "contiguous" memory problem.)
see the 10.6.8 was installed freshly about 3 weeks ago. this MM functions as a server doing faxes, answering machine, print server and a few emails a day (iMovie is not even installed neither is Flip4Mac). so it is not like in heavy use. so I fail to see how their can be fragmentation.
Did you "wipe" the drive prior to your install? If not, there is the possibility of carryover fragmentation. I just checked my startup drive and found 709,236 of 1,991,704 items out of optimum order (36%) since my last routine maintainence optimization, drive mechanics test, and general "dusting & cleaning" exercise. Here is the graph:
Of course, I may process an average of 100 GBs to 200 GBs of data during a typical day of copying, converting, and storing video content. (Yesterday was a non-typical day since I had to "panic" backup 597 GBs of DVD images from one RAID drive to another because one array appeared to require reformatting following its latest firmware and dashboard updates. This was in the middle of copying a season of TV shows to my internal drive, converting them for TV use, adding them to my iTunes library, inserting metadata, and proofing the results. In any case, it appears my DroboPro will survive after all since I discovered this morning that the dashboard installer app as released by manufacturer support was probably faulty. (I.e., the embedded PKG file embedded within the installer application was opening Pacifist for installation rather than the Mac OS Installer.app as it should have done. In any case, I extracted the installer package from the app file, corrected the problem, and ran the PKG file manually to save the need of backing up another 7 TBs of data over the next week.)
In any case, to get back to your problem... It may be a good idea to simply see if you can find a program that will graph, disply, or otherwise reveal your current state of fragmentation. If the disk is not fragmented, then you can continue your search for an alternative solution. If it is highly fragmented, then you can try the defragmentation option and see it it works. In either case, it may help others if you post your results here for further review.
Best of luck...