In most countries there are two print controller options for the iR C4080. There is the internal Canon printer board and the external EFI "Fiery" print controller, called an imagePASS-H1.
If your iR C4080 is using the internal Canon printer board, then there are two print drivers available for Lion. The UFR2 v2.41 and the PS3 v3.51.
If the iR C4080 is using the Fiery then you can only use Postscript and it needs to be the correct Lion driver for the imagePASS-H1.
A quick way you can check which print controller you have is to open a web browser and type in the IP address of the iR C4080. This will connect to the internal web page of the copier and show which controller is being used (it will either say iR C4080 or imagePASS-H1).
So which one do you have?