I'm having a ton of problems since upgrading too. Gestures don't work right. Previous and forward swipe in safari either get stuck or they go back too many pages. I can't x out of tabs at times. (no x appears). Also when that happens, I can't quit safari at all. The quit option is greyed out. Have to force quit. Websites aren't rendering properly at times and I'm having some problems where my sound stops working entirely even with volume turned all the way up.
In short, this was a VERY sloppy release for Apple. Every new software has it's bugs in the begininng, but this is entirely unacceptable. Steve Jobs, should be rolling over in his grave. Then there's the fact that no pre mid-2011 macs can utilize the new mirrored airplay. Sure, it's in the product description (albeit burried way at the bottom), but when you're running a late 2010 mac, one doesn't expect to encounter any compatibility issues. This is a feature they advertised heavily. It should therefore be plastered at the top of the page in big red letters, and a note should pop up before it allows you to purchase, giving you the option to back out if you choose. I am tempted to call apple and demand my money back, because frankly, this upgrade is almost entirely useless to me, and with all the bugs, it's made my computer an unstable mess. Apple if you are reading, I'm a very unhappy customer, and I have a feeling I'm not alone!
musfique- As far as those sounds you're hearing, that is not a good thing. That seems like it's hardware related. I've had fans that were getting ready to die on one or two of my desktop PCs make screaching sounds, and of course hard drives have been known to do that too before failing, but isn't the new Macbook Pro Solid state? If it's solid state, I doubt it's a hard drive problem. Maybe it is fan related since you said you heard it while watching video. That would be when the fans kick in. Regardless, it's not normal and definitely something you need to get taken care of. I'd call tech support or take it into an apple store and get them to fix or replace it under waranty. Don't forget to back up your data just in case.
If anyone has any suggestions of the Safari bugs, I'm sure the rest of us are all ears!