I was having the problem with my external backup devise using Time Machine, and began to think it was my Drobo S since the Senior Apple Support Advisor said there was nothing wrong with the OS (10.8.2) based on the diagnostics gathered from Capture Data (an Apple piece of software he emailed me). So, I began working with Drobo Tech. Support, and they deduced from their diagnostics, that 1 of the 5 drives in the Drobo enclosure was defective. I removed it, and everything is fine. I'm connected via FW 800, and have the box checked to "put drives to sleep when possible" in energy saver. I have even reconnected some other drives and card readers to the Drobo unit via daisey chain as it had been in Lion. Everything is working fine now, and has been for about a week.
I returned the drive to Amazon, and ordered a new one of the exact size and kind to see what happens when I have all five bays filled with similar drives as the Drobo is intened to operate.
The drives I have are WD 2TB Red, which are designed for use in NAS backups.
Once I get the new drive I'll keep you informed.