OK, four hours in since clean restore on 4S fromiTunes. Excellent battery life so far. Here's what I did:
1. DId a clean restore and set up as new phone. Confirmed Wifi network connection. Added my work e-mail through Exchange and Yahoo mail. Also added about 900 songs and 10 podcasts (all via cable and not Wifi). Charged to 100%. Sent a couple of e-mails to and from to confirm e-mail works. DID NOT add any Apps (as I suspect this is where the problem is).
2. From Hour 0 to Hour 2, iPhone in stand by mode most of time. Other than a couple of checks of lock screen to see battery level, no use. Battery at 100%.
3. Hour 2 to 3. Took a photo and sent by e-mail. Battery at 99%.
4. Hour 3-3.5. Set up Bluetooth connection to car, played one song at 80% volume on iPhone internal speaker. Battery at 98%.
5. Hour 3.5. Added NY Times and Boston.com Apps via cable to Itunes (not Wifi). Read one story in each. Charged battery back to 100%. Back of phone a tiny bit warm from what feels like ordinary use of processor. Shut both apps and locked screened phone.
6. Hour 3.75. Phone on standy by for last 15 minutes. Back of case is cold. Battery at 100%. Will continue to add back apps one or two at a time.
Working Hypothesis: One or more of my Apps has a compatibility issue with iOS6, It keeps crashing and restarting, keeping processor going until battery drained. Will avoid testing Facebook (several posters have pointed to this as potential culprit) until I have reloaded and confirmed that all of my "every day" apps are working.