I have an iPad2 and an iPhone5 both running iOS6 and using the AT&T network.
My iPhone does not appear to be exhibiting any problems, but my iPad allegedly racked up 1GB of cellular data on Saturday (according to my online AT&T account). I was streaming the Ryder Cup coverage to my iPad that day, but was doing it over my home wi-fi network and not on the cellular network. The usage data (found under Settings>General>Usage>Cellular Usage) said I had consumed 25.5MB of cellular data since upgrading to iOS6 (when I last reset the stats).
I called AT&T and identified the problem. The rep insisted that the issue was mine and that I couldn't have been connected to my wi-fi network, but nevertheless agreed to waive any overage charges if I exceed my 2GB data plan in the remaining 25 days of my billing cycle.
I asked, and was able to speak to a supervisor to see if they would admit there was an issue. I pointed out that Verizon had already admitted the problem existed for them and pointed him to several reports on the web of the concern existing for AT&T as well. He was polite, but would not admit to any problem...
My recommendation to users on AT&T using iOS6 is to regularly check your data usage online and call AT&T if you see a problem -- they will almost certainly waive any overage fees.