Which OS version (Yosemite? Lion? etc) and the gpu should be front-and-center if different from the original post (which lacked details also).
Some of the mystery behind and experience of others:
http://forums.macrumors.com/showpost.php?p=20703758&postcount=1939
http://forums.macrumors.com/showthread.php?t=1440150&page=78
Some got tired of all the issues with "unsupported" and have gotten either EVGA Mac or flashed a PC GTX 680 to avoid problems.
My own "rule number one" is to always have a bootable clone backup of current system, and only then apply updates.
In the past it was possible to apply updates to non-boot drive, even a sparse disk image, and leave the working boot system untouched, that nice feature got taken away, making a clone even more important. There are no painless updates and actually security updates have a habit and long history of breaking more things than a "regular" system update. Not sure why but see that reported all the time. Which is why some like to even hold off for a week, though of course we all are told how security updates should not be deferred, though prudence in applying and being sure it doesn't break essential programs and hardware is as if not more important.
So I always read up on a couple good Mac feedback news sites.