My Safari Crashes often when I hit Command-A to select all the text in a window. It was happening about once a week but it just happened twice in a row. Safari used to be very reliable but now it's very buddy.
Quit Safari if it's open.
Now open the Finder. From the Finder menu bar click Go > Go to Folder
Type or copy/paste: ~/Library/Caches/com.apple.Safari
Click Go then move the Cache.db (or ApplicationCache.db) file from the com.apple.Safari folder to the Trash.
If it crashes again, post a crash report in your reply. The entire report including the, "binary images" section.