I run my iTunes music over the following network:
MacMini wireless to...
Main AirPort Extreme with a wired (old) and wireless AirPort Express (old).
wireless to
Remote Extreme with a wired AppleTV (new), wireless AppleTV (old), and a wireless Express (old).
All was fine until the last weeks or so, which I think may have corresponded with an iTunes or other software update. I've also been noticing persistent difficulty keeping a connection with i-Devices running the Remote app.
I'm seeing much the same thing many of the posters are: an unexplained simultaneous drop of all the Expresses after a few minutes of play. The only remedy is to turn off the WiFi on the host MacMini, and turn it back on. The connections reestablish, only to drop again. Do nothing and the connection will mysteriously reappear after a spell, only to drop again.
I've tried all the remedies here, including setting all the devices to static addresses, disabling IPv6, using AirFoil, saying voodoo chants, etc, etc.
There would appear to be some basic incompatibility between the AEX's and the MacMini, particularly apparent when being used in iTunes.
Hopefully this will be addressed in some fix along the way. Very frustrating.