It should be easy in iSync: just make sure that the Palm Desktop 4.2.1 in installed, then add your device to iSync using the
Enable Palm OS Syncing… option under the iSync
File menu.
If you have already installed the Missing Sync, you will have to use the Uninstaller application provided by Mark/Space to restore both iSync and the HotSync Manager to working order. This function is only available with the Missing Sync for Palm OS version 5.1 or later. If you have an earlier version, you will likely have to reinstall both the Palm Desktop and iSync, in that order.
Using the Missing Sync for Palm OS is potentially more problematic, as it is not listed as explicitly supported. That may be simply because, from their point of view, the product was cancelled and never released.
To use your SPH-i550 with the Missing Sync, you will first need to synchronize it successfully with iSync, because your iCal and Address Book data files need to be up to date. This is because you are required to overwrite the contents of your smartphone with the information stored in iCal and the Address Book the first time you synchronize using the Mark/Space conduits. This really is an important requirement, and choosing to disregard it can cause serious data corruption on subsequent synchronizations.
After synchronizing one last time with iSync, be sure that you back up the data files from both using the built-in backup options available under the File menu of each application before proceeding with synchronization using the Missing Sync.