I am having the same problem and it is very annoying and frustrating the insanity out of me.
Been going on for like 2 months now. Any time I click open with i get the spinning beach ball and slower is slow to respond and not acting like normal.
I tried everything including running the frameworks thing but I cant get it to go away.
Should i start up in disk recovery mode and re-install my OS?
Will this delete all my application preferences/settings and make me enter new serials again?