using SSD for applications and OS

OS X makes it easy and has supported having home account on any volume anywhere for 10 yrs, since 10.2.2 from inside Accounts control panel with little to no work.

RESEARCH the reliability of the OWC PCIe SSD first. It is subject to corruption. It does not really work pre-2009 but you are safe in that regard.

There are guides how to move and setup an home account and SSDs. On the forum, google,

Even the terminal which will, is rather easy and allow and best when handling more than one (like 20 users) but no need for you.

If you can't find it from Google someone will hand it on a spoon...

You can move your home folder as follows.

1. WARNING: This procedure is for advanced users only. Some applications may not work as expected, or may not work at all, if the home folder is not in its default location.

2. Back up all data. Do not proceed unless you know how to undo these steps without having to ask for help.

3. If you do this wrong, you could end up with a bricked machine and no way to recover without losing data.

4. Copy your home folder to the desired location. Your home folder is the one with your name on it. Do not copy the "Users" folder unless you're moving the home folders of all users.

5. Select  ▹ System Preferences ▹ Users & Groups. Click the lock icon and authenticate. Right-click or control-click your name in the account list and select Advanced options from the popup menu. In the sheet that opens, change the location of the home directory. Log out and log back in.

6. Test. If you have problems, reverse the above steps. If you got this far, you should have no trouble doing that. If everything works as you expect, delete the original home folder.

Another option if you're running OS X 10.8.2 -- the one I prefer -- is to combine the SSD with an HDD in a Fusion Drive. That way, you have single volume for everything, and adaptive allocation of data between devices. For information see:

Understanding Apple's Fusion Drive

Apple - iMac - Performance

Mac mini (Late 2012) and iMac (Late 2012): About Fusion Drive

Fusion drive on an old MacBook Pro

I'm not advocating this setup -- it's an unsupported hack -- but as a professional Mac user you should be aware of it.

Spoon? This one?

Here are two similar recipes and discussions on the subject of moving the Home folder -- no Terminal required

http://www.jcsenterprises.com/Japamacs_Page/Blog/00E03B83-1ADA-406E-A940-396D39F 598EA.html

http://chris.pirillo.com/how-to-move-the-home-folder-in-os-x-and-why/

This also raises the question if you move your Home Directory what is the story on Home Directory programs like mail or your Documents.

Mac OS X is inherently a Multi-User system.

Applications, such as the Mail Application, are stored in the Applications folder at top-level. By default, any User who logs in uses that Application with their own individual email data stored in their own Account in the /Users directory. There is no need to have multiple copies of the Application.

[In fact if you try to make a copy of Mail Application somewhere other than in Applications, you will probably end up with your Mail program disabled because it is a huge Security Risk.]

Your Documents are by default stored at /Users/<your_name>/Documents. When you use the recipes or Linc Davis' detailed procedure, you are re-assigning the location of <your_name> Directory. All your document references move with that re-assignment (you still have to manually duplicate the <your_name> Directory), and all the Applications stay in the same place in the /Applications folder at top-level.

I prefer a setup where the original Admin account is used ONLY for Administration, and is left alone on the Boot Drive. User Accounts (including my own) have no Admin rights, and are all moved off the Boot Drive.

You can get even more extreme than having User files on a separate drive. They can be on a different computer. I run my home Network as if it were a School setup with computer clusters (because I do some school consulting). User Accounts are all on a separate computer running Mac OS X Server. Any User can log on at any computer and their files are instantly available (from the Server).