I would - I have a 512GB Crucial m4 SSD and I've had TRIM enabled since I installed the SSD. To find out more about TRIM - see this article from Wikipedia. It just keeps you SSD 'healthy'.
And I use TRIM Enabler to enable TRIM - just be aware that with every software update (going from 10.7.3 to 10.7.5 - which I would recommend doing) you must use TRIM Enabler AGAIN.
I've never had an issue with the app - like I said, though, (and this holds true even if you use Terminal to enable TRIM support) each time that there's a .1 update to OS X, you must enable TRIM again. Not too big a deal - you just have to remember to run it again, restart, and - voila! - TRIM support is back.