I would - I have a 512GB Crucial m4 SSD and I've had TRIM enabled since I installed the SSD. To find out more about TRIM - see this article from Wikipedia. It just keeps you SSD 'healthy'.
And I use TRIM Enabler to enable TRIM - just be aware that with every software update (going from 10.7.3 to 10.7.5 - which I would recommend doing) you must use TRIM Enabler AGAIN.
Here's the System Info on my SSD:
Capacity: 512.11 GB (512,110,190,592 bytes)
Serial Number: 000000001205032CC056
Native Command Queuing: Yes
Queue Depth: 32
Removable Media: No
Detachable Drive: No
BSD Name: disk0
Medium Type: Solid State
TRIM Support: Yes
Partition Map Type: GPT (GUID Partition Table)
S.M.A.R.T. status: Verified
Capacity: 209.7 MB (209,715,200 bytes)
BSD Name: disk0s1
Capacity: 511.25 GB (511,250,432,000 bytes)
Available: 369.54 GB (369,544,036,352 bytes)
File System: Journaled HFS+
BSD Name: disk0s2
Mount Point: /
Volume UUID: A010BEA0-E0B9-3EDC-B13D-BAB093AC4E57
Capacity: 650 MB (650,002,432 bytes)
BSD Name: disk0s3
Volume UUID: 3F8BD124-7B04-32BB-ABDA-D56C533E81F6
As you can see, TRIM is enabled.
I've never had an issue with the app - like I said, though, (and this holds true even if you use Terminal to enable TRIM support) each time that there's a .1 update to OS X, you must enable TRIM again. Not too big a deal - you just have to remember to run it again, restart, and - voila! - TRIM support is back.