Are there special precautions to take IPad on plane?

Put it into Airplane Mode.

Be careful when the flight atendants are serving liquids and handing them overtop your iPad to the person next to you.

And don't forget to take it with you when you disembark.

The biggest one, going by posts on these forums is, DON"T LEAVE IT BEHIND WHEN YOU DISEMBARK THE PLANE 😉

In the crush to get up and out at the end of a flight, more than one person has forgotten their iPad tucked into the seat pocket in front of them.

And NEVER, EVER leave it in your checked baggage

I've flown several times with mine with no problems. You don't have to place it out separately in a bin when going througy security . . . I asked. I leave it in my briefcase. I don't recall setting it to Airplane Mode during my last trip. And, the other posters are correct in saying that it would be easy to forget it in the seat pocket, so be careful. Otherwise, it's great entertainment. Remember to download movies beforehand.

Treat it no differently than you would treat it anywhere else that you are using it. Be careful as always, don't leave it unattended if you have to use the restroom, turn on AirPlane mode when instructed, and other than that - enjoy it. Having a movie or a couple of books - or games that you can play without WiFi - is a great way to pass the time on a flight.

Now that we're up to what content to include, if you want to listen to any content make sure you bring earbuds/headphones. That's kind of a no-brainer when travelling with an iPod but it might not be on your usual list for your iPad. Noise-blocking ear buds or noise cancelling headphones would be preferred. Planes are louder than you might think.

And make sure to fully charge it before leaving home