Seems that not only am I getting constant random beach balls and eventual unresponsive programs, but I am also getting regular device driver corruptions. These are all third party devices that have "qualified drivers for this OS". Come on Apple get it together.
Disgruntled Pro Tools user.
Try doing some basic maintenance.
For the spinning beach balls and unresponsive programs, if the above doesn't solve the problem:
Try setting up another admin user account to see if the same problem continues. If Back-to-My Mac is selected in System Preferences, the Guest account will not work.
If the problem is still there, try booting into the Safe Mode. Shut down the computer and then power it back up. Immediately after hearing the startup chime, hold down the shift key and continue to hold it until the grey Apple icon and a progress bar appear. The boot up is significantly slower than normal.
If you haven't installed the 10.8.2 supplemental update, maybe that might help. There are 2 and since I don't know the age of your computer, I'll post both:
You can try re-installing Mountain Lion by booting into the Recovery Partition (command - R). Ugly, but has solved a lot of problems.
Once again, thanks for the thoughts. I certainly would try to avoid a re-install if I can. My setup is in a studio and would be hard pressed to suffer the downtime. Last resort for sure.
As for the age of the computer, it is brand new. About a month old. I have done the 10.8.2 update...however, I will try the supplemental.