Try these suggestions. Hopefully, one of them will work:
http://support.apple.com/kb/HT1151 USB & FireWire Tips and Troubleshooting
Install the Gutenprint and Gimp-Print for Mac OS X (10.2 and later) drivers.
Select the language you wish to use, and then choose "Disk Utility" from the menu bar.
Your HD should appear in a panel on the left hand side of the window which opens. Select it and then click on the "repair disk" button in the right hand section of the window.
If Disk First aid is unable to complete the repair you will need to use a stronger 3rd party utility like DiskWarrior or TechTool Pro.
Once this process has been completed restart your computer.
I deleted my 2 printers (there were 2 of the same listed) within the print and fax preference window and added it back and now I can print again. I guess after multiple reinstalls of the Epson software, I ended up with 2 of the same printers and it got confused as to which one to select. But I still can't get Epson Fax to open up, which was my problem to begin with. It tries to open with a gray preview window and a gray main window, then after 4-5 seconds, it quits and I get an error massage: "The application EPSON Scan quit unexpectedly". When I click the relaunch button, the same thing happens again. There is nothing wrong with the printer as I can print and copy and I can scan if I plug the printer into another computer. I just can't get the EPSON scan application to open on my main compute which has worked fine for 5 years until today. I just now tried to select the printer and scan form the Apple Image Capture application. When I do, Epson Scan almosts opens, but Image Capture crashes, so the problem could be a bug in the Image Capture app. The error message says: The problem may have been caused by the UI plug-in.Any sugesstions out there to fix Image Capture?
How about uninstalling the Epson software using its uninstaller and then trying Image Capture. I have a Brother printer/scanner and only have the software available from the Apple site to run it - not the software that came with the printer of is available on Brother's website. Image Capture opens and works fine without it opening any other software. I think IC is a standalone app.