It's really great that you're taking the time to help me. I did several of the tests you recommend over the last two or three days. It always shows that the iPod/iPhone/iPad isn't present. Here's more. I got a Norton tech to help me yesterday and it isn't the anti-virus, as we uninstalled everything and it still didn't work. I went deeper into the system through the control panel, and found the device detected on the appropriate USB port, but it won't show up in "My Computer". Two of the three devices show up on another PC, (I didn't test the third) so I'm leaning to something in iTunes because every other USB device I plug into the Vista ports shows up quickly and works perfectly (thumb drives, wireless mouse, camera, etc). I already unistalled all Apple software and downloaded new, but the problem still exists. I have restarted, unplugged, you name it and the devices aren't showing up. I can't wirelessly sync either because one has to set that up through iTunes prior to doing it.