Q: Any good anti-rootkit and anti-keylogger for OSX ?

Start with some reading about Mac and malware from an experienced voice in this forum: http://www.reedcorner.net/mmg/

The reedcorner.net link is a great read. For rootkits, you can download and compile the Rootkit Hunter project (http://rkhunter.sourceforge.net), though it is a command-line based tool and is not a quick all-in-one scanner like you're looking for.

First, there's no software out there that can reliably detect all possible keyloggers. There are legit keyloggers that won't be detected by everything, for example. If you think that someone malicious has had access to your computer, either physical access or through a back door installed through some other method, then the only reliable response is to erase the hard drive and then reinstall the system and all applications from scratch.

In addition, the term "rootkit" (when used correctly) is a very specific kind of malware that is installed to give the hacker escalated root-level access to the computer. In modern single-user systems, this is not particularly meaningful, for a variety of reasons. Fearing rootkits and not more general malware is kind of like going to Africa and being on your guard against lions, but not against hyenas, hippos, elephants, leopards, poisonous snakes, etc.

What is the specific issue you're trying to solve? If it's just a general concern about protecting yourself against malware, see:

http://www.thesafemac.com/mmg

(Formerly at the reedcorner address the others have referred to.)

Deepest apologies.  I now recall you telling us you changed location and updated content.

Is there any reliable anti-rootkit and anti-keylogger software for OSX ?

No.

Deepest apologies.  I now recall you telling us you changed location and updated content.

No problem, the reedcorner address still works too.

I know this is super late answer... but I would like to add it anyways for the future. - on my experience, as soon as your computer has been compromised.. there is no way to know (By simple users means) how deep an infection is. So the best, it's not to play fool and do not believe that this many not happen to you because you have nothing important, the best it's to just backup all your data files and erase completely your computer start over from scratch. never use software from Piratebay for example or cracked software, ALL OF THEM has been compromised.

even if you have nothing to loose, the hackers may use your computer as a bridge to attack others entities or agencies and your computer may be the one that will show up like the one who has doing it. so you don't want it, for sure.

So if you computer has been compromised.. that's it - backup data, erase it all from scratch and start over no matter how long it may takes.