I have tried ALL of the recommendations made so far. My iPod Shuffle 2 gen palys and charges fine, but the latest iTunes will NOT recognize the device, so I cannot manage any music on it. It loaded an initial playlist, but no more interface is possible at this point. Even the latest Mac iPod utility is "grayed out" when activated. No reset is possible, either. USB cord fine, iTunes working fine, playback fine, charging fine.