Experiencing 'rolling glitches' on my iMac 27 since last update of OS X 10.8.3

Any suggestions other than turn it off, turn it on again?

Running with G Drive and only programs bought through the iStore, and I am able to turn off the computer and restart it and get on with my work.

Initially it was acting up on every program but I just kept working and it was getting around the problems. That may not have been a good idea.

I am having problems with cross linking, I am an artist and it takes about 4 changes on a file before I can use it. The usual crop, resize, change to png, save as a program files for future adjustments and the png into the folder that needs it.

Endless interruptions that I cannot avoid can cause me to misfile, misname, I have smart folders and a special sort on the All My Files. I noticed if I turned that off, most of the problems cleared up. Is that the source of the problem?

I could use some help, I came from the wonderful world of Windows, and it is a bit of a transition. I don't run Windows on my fabulous iMac. This iMac is the most incredible, marvelous, ingenious, admirable thing I have ever used. So I kinda figure if there is a problem it would most likely be an operator problem. %^}