Can I upgrade my IPad 1G from IOS 4.2.1 to IOS 4.3, Can I upgrade my IPad 1G from IOS 4.2.1 to IOS 4.3

Update it from iTunes on a computer as described at the bottom of this article; devices running an iOS version prior to 5.0 can't be updated straight from the device. It will be updated to the latest compatible version.

The third generation iPod touch and original iPad can’t be updated past 5.1.1.

(82043)

Note: you can't update it to 4.3. Followin Niel's directions you can update it to 5.1.1., though.

If you have an iPad 1, the max iOS is 5.1.1. For newer iPads, the current iOS is 6.1.3. The Settings>General>Software Update only appears if you have iOS 5.0 or higher currently installed.

iOS 5: Updating your device to iOS 5 or Later

http://support.apple.com/kb/HT4972

How to install iOS 6

http://www.macworld.com/article/2010061/hands-on-with-ios-6-installation.html

iOS: How to update your iPhone, iPad, or iPod touch

http://support.apple.com/kb/HT4623

If you are currently running an iOS lower than 5.0, connect the iPad to the computer, open iTunes. Then select the iPad under the Devices heading on the left, click on the Summary tab and then click on Check for Update.

Tip - If connected to your computer, you may need to disable your firewall and anitvirus software temporarily. Then download and install the iOS update. Be sure and backup your iPad before the iOS update. After you update an iPad (except iPad 1) to iOS 6.x, the next update can be installed via wifi (i.e., not connected to your computer).

Tip 2 - If you're updating via wifi, place your iPad close to your router to preclude getting a corrupted download.

 Cheers, Tom 😉