No. You'd need to use another eMail client software. Probably Entourage could do this.
But before you switch, think about the following:
Notifications can be disabled by the recipient.
There's no guaranteed way of making sure an email arrives. You can improve reliability by using
GnuPG or something alike, but it will not replace a registered letter where it really counts.
I usually ask a simple, sometimes even non-related question in the end of important emails, so I have a chance of getting an answer
if the recipient read through my whole email. If I don't get an answer in time, I always have a pretence to make a phone call.
Regards
Greg