Which OS X software version are you running?
Is this Mail.app or another mail client?
Do you get any diagnostics or other feedback when you select the embedded links in the emails (and it fails)?
Does your web browser correctly open the same URLs, when entered directly into that?
Has anything recently changed with your configuration?
Thanks for replying. I am running 10.8.4
It is the Apple Mail app. I get no feedback other than "Error. No associated application could be found." when I click on the website link embedded in the email.
My web browser opens all urls when entered manually. Nothing has changed, just bam... different.
Any insight would be great!