Mail CPU usage spikes periodically - does not crash
I have a 13" MBP with Retina display, running 10.8.4. Several times a day, the CPU usage spontaneously spikes to 100-200% and the fans go nuts. I've been trying to pin it to an activity, but I don't usually notice it until the sound of the jets taking off fans spinning up alerts me and Mail is often in the background. So I can't tie it to anything yet.
I'm running 5 Gmail/Google Apps email accounts. Even though CPU usages spikes badly, Mail doesn't seen to become less usable - the main bummer is the fans spinning up which can be quite distracting in meetings or on Skype calls. After a few minutes, Mail calms down and things go back to normal, or I can kill/restart Mail.
Here's what the resources look like when this happens:
I am running the current version of InDev's Mail Act-On but I uninstalled it and it made no difference - still the same spikes several times a day. No other add-ons in Mail. I've tried resetting the SyncServices folder based on some other posts here.
Any tips on how to resolve this?
MacBook Pro with Retina display, OS X Mountain Lion (10.8.4)