I had a similar issue. I rotated my images in Preview on the Computer I used for scanning the negatives in TIFF format. For some reason they were not displayed anymore in Preview, but I could still view them by pressing space from the Finder. I noticed that they were translucent, but I didn't think much about it. The computer was running an older version, 10.6.8, so I figured it is a bug and everything will be fine at home on the newer version.
As soon as I came home and wanted to have a look at my photos, I still wasn't able to view them. I found this discussion but the proposed fix did not do the trick. I went back to Digital Photo Lab from our university where I scanned the Photos. I wanted to revert the photos to the original but the option was grayed out (On some other thread this was possible for some people). So I applied the "Black and White" color profile again and chose "Save As" - an option I did not have at home (different versions). The prompt included a tick "Include Alpha", ticked by default. I unticked it, saved under a different file name et voilà! I got my photos back!
Apparently it was the alpha channel that was screwed up. Also explains why the photos were translucent with the Space-Preview from Finder. Also, this made the files significantly smaller - probably half the size if I'm not mistaken. I'm just super happy I got my photos back and don't have to scan them again!
Hope this helps somebody else!
Best
Tim