Dock and menus suddenly require clicks
The last few months I've noticed an odd behavior in my MacBook Pro, a mid-2010 15" model with 2.66GHz i7 and 4GB of RAM. It is running OSX 10.8.4, patched to current. I have the dock configured for auto-hide, no special access features enabled. I don't recall this behavior under 10.7 and earlier, and it seems to be much more frequent the last six months or so.
The problem will typically occur after a few days of use. On awakening from sleep, the dock will no longer unhide when the cursor is placed at the appropriate screen edge. At the same time, menu items that normally auto-expand on mouse-over require mouse clicks to expand. As an example, the finder 'View' menu normally requires a click to open, but thereafter is highlighted as one mouses over it. Any with a submenu automatically expand as you mouse over that particular entry. When the problem occurs, the 'View' menu will open on click, but lines do not highlight as you mouse over them. If you click on a line, it then highlights. If the line has a submenu, the submenu only opens if you click on the arrow mark.
My work usually requires keeping on a number of issue for days on end. To manage this I make liberal use of Spaces and have a second screen. So while a reboot does fix the problem, it also requires abandoning most of my ongoing work and restarting it afterwards.
As I said, it's become much more of a problem in the last six months or so. In that period my employer has loaded a fair amount of intrusive software onto the machine, but it definitely began before that.
MacBook Pro, OS X Mountain Lion (10.8.4), 4GB RAM